(ibakin-100) Imatinib Mesylate INN 100 mg Tablet

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  • Product Description:

Ibakin is orally administered film-coated tablet which contains Imatinib mesylate INN. Imatinib is a small molecule kinase inhibitor. Imatinib Mesylate is designated chemically as 4-[(4-Methyl-1-piperazinyl) methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl] amino] phenyl] benzamide methane sulfonate. Imatinib is a protein-tyrosine kinase inhibitor that inhibits the BCR-ABL tyrosine kinase, the constitutive abnormal tyrosine kinase created by the Philadelphia chromosome abnormality in CML. Imatinib inhibits proliferation and induces apoptosis in BCR-ABL positive cell lines as well as fresh leukemic cells from Philadelphia chromosome positive chronic myeloid leukemia. Imatinib inhibits colony formation in assays using ex vivo peripheral blood and bone marrow samples from CML patients. In vivo, Imatinib inhibits tumor growth of BCR-ABL transfected murine myeloid cells as well as BCR-ABL positive leukemia lines derived from CML patients in blast crisis. Imatinib is also an inhibitor of the receptor tyrosine kinases for platelet-derived SCF-mediated cellular events. In vitro, Imatinib inhibits proliferation and induces apoptosis in GIST cells, which express an activating c-kit mutation.

  • Product Features:

Product Name  ibakin-100
Generic Name  Imatinib Mesylate INN 100 mg Tablet
FDA Approved Indications
  • Newly Diagnosed Philadelphia Positive Chronic Myeloid Leukemia (Ph+ CML)
  • Ph+ CML in Blast Crisis (BC), Accelerated Phase (AP) or Chronic Phase (CP) After Interferon-alpha (IFN) Therapy
  • Adult patients with Ph+ Acute Lymphoblastic Leukemia (ALL)
  • Pediatric patients with Ph+ Acute Lymphoblastic Leukemia (ALL)
  • Myelodysplastic/Myeloproliferative Diseases (MDS/MPD)
  • Aggressive Systemic Mastocytosis (ASM)
  • Hypereosinophilic Syndrome (HES) and/or Chronic Eosinophilic Leukemia (CEL)
  • Dermatofibrosarcoma Protuberans (DFSP)
  • Kit+ Gastrointestinal Stromal Tumors (GIST)
  • Adjuvant Treatment of GIST
Packaging Ibakin-100 Tablets: Each commercial box contains 3×10’s tablets in Alu-Alu blister pack.
Prescribing Information  Ibakin-100 (PDF)
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(ibakin-100) Imatinib Mesylate INN 100 mg Tablet

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